Sciences: Unit 2 Biology - GMOs

An article outling the development of CRISPR and outlining uses, issues and concerns.

A brief, simple explanation of the CRISPR technique.

Explore the science of the groundbreaking technology for editing genes, called CRISPR- Cas9, and how the tool could be used to cure diseases.
From the smallest single-celled organism to the largest creatures on Earth, every living thing is defined by its genes. With recent advancements, scientists can change an organism’s fundamental features in record time using gene editing tools such as CRISPR. But where did this medical marvel come from and how does it work? Andrea M. Henle examines the science behind this new technology.

Links to web resources on discussions relating to the use of CRISPR technology.

An overview of CRISP-Cas9, including the technology, development, applications and implications.

A brief introduction to CRISPR genome editing technology, uses, and ethics, including a video explaining the procedure.

You need to log in to State Library of Victoria to access. This article discusses the historical timeline-based advancement of CRISPR, CRISPR/Cas9 as a gene-editing technology, the structure of CRISPR, and CRISPR as a diagnostic tool for studying emerging viral infections. Additionally, utilizing CRISPR/Cas9 technology to fight viral infections in plants, CRISPR-based diagnostics of viruses, pros, and cons, and bioethical issues of CRISPR/Cas9-based genomic modification are discussed.

In this article, various applications of CRISPR-Cas9 technology, especially in medicine and agriculture, are described and ethical issues related to genome editing using CRISPR-Cas9 technology are discussed. The social and bioethical concerns in relation to human beings, other organisms, and the environment are addressed.

You will need to log in to the State Library of Victoria to access. This review summarizes the potential of these genome editing techniques and their applications in human embryo treatment. It also analyses the CRISPR-Cas limitations and the possible genome damage caused in the treated embryo. Finally, the articles discusses how all this impacts the law, ethics and common sense.

This article outlines ethical issues relating to the CRISPR technique, including its use and purpose.

You will need to log in to the State Library of Victoria. The latest discovery of CRISPR/Cas9 technology seems more encouraging by providing better efficiency, feasibility, and multi-role clinical application. This later biotechnology seem to take genome-engineering techniques to the next level of molecular engineering. This review generally discusses the various gene-editing technologies in terms of the mechanisms of action, advantages, and side effects.

You will need to log in to the State Library of Victoria. In the last decade, genome editing technologies became very effective and several clinical trials have been started in order to use them for treating some genetic diseases. Interestingly, despite more than 50 years of discussion about the frontiers of genetics in human health and evolution, the debate about the bioethics and the regulatory practices of genome editing is still far from satisfactory answers.

This article reviews the art, applications and potential risks of CRISPR-Cas system in genome editing. It highlights the patent and ethical issues of this technology along with regulatory frameworks established by various nations to regulate CRISPR-Cas-modified organisms/products.

Log in to EBSCO via GenConnect to access. The author reflects on concern related to use of CRISPR gene-editing technique for modification of human genome in a way that could have effects on future generations. He states that decision making on issues associated with human gene-editing will be guided by the U.S. National Academy. He mentions risk associated with other science technology such as genetically modified (GM) organisms, nuclear power and chemical toxicity.

Overview of research paper from scientists in the US showing that they have successfully edited human embryos to correct a mutation that causes an inheritable heart condition. Discussion of results and implications.

An article outlining the potential benefits of the use of CRISPR technology, as well as the bioethical and legal regulations required for the application of this technology.

Log in to EBSCO via Genconnecrt to access. The article focuses on the ethics of changing the human genome and the challenges faced by researchers with the risks and benefits of gene editing. Topics discussed include gene editing is done faster and quicker with the clustered regularly interspaced short palindromic repeat system (CRISPR/Cas9); and the system uses RNA to guide the Cas9 enzyme into the nucleus of a cell where CRISPR snips and repairs genetic mutations or adds genetic material.

This article conducts a systematic review of the reasons reported in the academic literature for and against the development and use of genome editing technologies in animals.